Boost skin repair, improve elasticity and restore healthy, long-lasting hydration with polynucleotide treatment at our Oxford clinic.
Polynucleotide Treatment Overview
Polynucleotides are one of the most advanced regenerative injectable treatments available today. Rather than adding volume or simply boosting hydration, they work at a cellular level to repair, rebuild and rejuvenate the skin from within. At Cannelle Skin Clinic in Oxford, all polynucleotide treatments are performed by Dr Mattia Parducci, ensuring a medical, anatomically informed and highly precise approach that delivers natural, healthy looking improvements.
Polynucleotides have quickly become a leading choice for patients wanting visible skin improvement without changing their facial structure. They are particularly effective for crepey texture, fine lines, inflammation, dullness, dehydrated areas, acne scarring and early or advanced signs of ageing. Because they repair the skin’s underlying architecture, the results are progressive and long lasting.
This treatment is suitable for a wide range of areas including the face, under eyes, neck and hands. Patients looking for long term skin improvement rather than structural enhancement often find polynucleotides to be one of the most transformative solutions available.
Polynucleotides are chains of purified DNA fragments that stimulate the skin’s natural repair processes. When injected, they activate fibroblasts and encourage higher levels of collagen, elastin and extracellular matrix components. They also have anti inflammatory and hydrating properties, making them ideal for compromised, thinning or ageing skin.
Unlike dermal fillers that add volume or shape, polynucleotides behave like a regenerative scaffold. They help rebuild damaged tissue, improve microcirculation, promote healing and encourage new collagen formation. Over time, the skin becomes firmer, smoother and more elastic, with a healthier, more rested appearance.
Polynucleotides are particularly effective in delicate areas where fillers can appear heavy, such as under the eyes. They strengthen thinning skin, reduce crepey texture, improve hydration and soften early fine lines without adding any bulk.
Most patients undergo a course of two to three treatments spaced two to four weeks apart. Improvements begin gradually and continue to develop for several months as the skin regenerates.
Your treatment begins with a consultation with Dr Mattia to assess your skin’s condition, concerns and suitability for polynucleotides. The injections are placed carefully into areas requiring regeneration, such as the under eyes, cheeks or neck. A topical anaesthetic can be used, though most patients find the procedure comfortable due to the fine needles and gentle technique.
Small bumps may appear at the injection points immediately after treatment. These are normal and settle quickly as the product disperses into the surrounding tissue.
You may notice mild swelling, small bumps or slight redness at the injection sites, which typically resolve within several hours. Tenderness can occur but is usually minimal. Most patients return to daily activities immediately after treatment.
Following your treatment, small bumps appear initially but start to settle within the first twelve to twenty four hours. Over the first two weeks, the skin begins to feel more hydrated and supple. As collagen and tissue repair accelerate, improvements in firmness, smoothness and texture continue to develop over four to six weeks. With a full treatment course, results progress even further, creating a healthier, more youthful appearance that lasts for several months.
After your polynucleotide treatment, avoid touching or massaging the treated areas to ensure even distribution of the product. Intense exercise should be avoided for twenty four hours, and heat based activities such as saunas and hot yoga should be avoided for forty eight hours. Keep the area clean and avoid makeup for at least twelve hours. Regular use of SPF will help protect the skin as it regenerates, supporting optimal results.
Our patients return to us year after year for natural, balanced results. Every review reflects our commitment to precision, safety and a personalised approach to aesthetic care.
I had two waxings and a biofacial today. Holly was excellent, knowledgeable, and impeccable in her attention. The products also felt really lovely – the hot wax was painless and the facial products felt luxurious. The whole experience was the best I’ve ever had. Will come back.
I go to Cannelle for facials, manicures and pedicures. They are professional, skilled, and attentive to my needs. It’s a lovely and relaxing environment. Mursal gives such wonderful treatments. She is very knowledgable about skin care and very gentle in the application of the products. I see her every 6 weeks for a facial and my skin has never looked better.
Patients often choose polynucleotides because they want natural, long term skin improvement without altering the shape of their face. At Cannelle in Oxford, the journey usually begins with an initial treatment to activate collagen and begin repairing the skin. A second treatment two to four weeks later enhances this effect, and some patients choose a third session for deeper rejuvenation.
Under eye rejuvenation is one of the most popular uses, as polynucleotides help strengthen thin, crepey skin and reduce fine lines without the heaviness that filler can sometimes cause in this delicate area. Other patients choose polynucleotides to improve early ageing, textural changes or dullness across the face or neck. As the skin continues to repair itself, results become more visible and continue to improve for several months.
Polynucleotides offer a powerful, regenerative approach to skin rejuvenation by repairing and rebuilding the skin’s structure at a cellular level. They improve elasticity, firmness and hydration while softening fine lines and restoring healthier, more resilient tissue. Because polynucleotides reduce inflammation and stimulate collagen and elastin, the skin becomes smoother, brighter and more even in tone and texture. Unlike volumising injectables, the result is a naturally refreshed appearance without any added fullness, making this treatment ideal for patients seeking long term skin repair and subtle rejuvenation that looks completely authentic.
We offer flexible regenerative treatment packages designed to improve skin quality, support healing and restore natural balance over time.
All bookings include a personalised consultation with your practitioner.
Final pricing may vary based on your treatment plan and clinical assessment.
“Pricing is per session unless the treatment name includes (x2), (x3), or another session quantity. Multi-session listings represent package pricing.”
All prices are in GBP
| Treatment | Price |
|---|---|
Polynucleotides | £350 |
Polynucleotides package of 3 | £870 |
Explore our frequently asked questions from patients in Oxford considering polynucleotides.
Polynucleotide treatments start from £300 at Cannelle Skin Clinic. The total cost depends on the number of sessions required, which is typically two to three. You can view our full price list here.
If you want to improve skin texture, fine lines, crepey areas or overall skin health without adding volume, polynucleotides may be ideal. They are suitable for many ages and particularly effective for delicate areas such as under the eyes.
Yes. Polynucleotides have an excellent safety record and are biocompatible. When administered by a medical practitioner such as Dr Mattia, the treatment is safe and predictable.
Mild swelling, bumps or redness can occur at the injection sites but typically settle within a few hours. Bruising is uncommon but possible.
Results usually last between six and twelve months. With repeated treatments, long term improvements in collagen and skin structure accumulate.
Most patients find the treatment comfortable. The injections use fine needles, and numbing cream can be applied if needed.
Common treatment areas include the under eyes, face, neck and hands. Polynucleotides are particularly effective in thin, delicate or crepey skin.
Most patients benefit from a course of two to three treatments spaced two to four weeks apart, followed by maintenance sessions every six to twelve months.
Yes. Polynucleotides work well alongside skin boosters, microneedling, laser rejuvenation and Profhilo. They are often combined with fillers for patients wanting both repair and structural enhancement.
Choosing polynucleotides at Cannelle Skin Clinic means receiving doctor led treatment from Dr Mattia Parducci, whose medical expertise ensures safe, precise and effective results. Based in Oxford, our clinic focuses on restoring skin health naturally through evidence based regenerative treatments. We create tailored treatment plans designed to meet your skin’s individual needs, supported by premium products and a calm, supportive environment that prioritises patient care and long term skin improvement.
Dr Mattia is an experienced aesthetic doctor with a background in Trauma, Intensive Care, and Plastic Surgery. His approach focuses on regenerative and anti-ageing medicine, using science-led techniques to support the skin’s natural repair systems and deliver refined, natural results.
At Cannelle Skin Clinic, your care is guided by a highly skilled medical and aesthetic team. Under the leadership of Dr Mattia Parducci, our Medical Director and Aesthetic Doctor, every treatment is built on clinical expertise and a commitment to natural, confident results. Supporting him is our Clinic Manager and Senior Therapist, Lauren Mariani, who leads our team of expert therapists. Together, they bring advanced knowledge, precision, and a genuinely warm approach to every patient journey.
Cannelle Skin Clinic is easy to reach from Oxford and the surrounding areas. We are located in Summertown, just 10 to 15 minutes from Oxford city centre. Oxford Station and Oxford Parkway are both around 10 to 12 minutes by taxi, with frequent buses running along Banbury Road that stop a short walk from the clinic. If you are driving, there is convenient on-site and nearby street parking, with additional short-stay options available around Summertown.
Nearby landmarks include Summertown shops, St Edward’s School, Oxford High School, Wolfson College and Cutteslowe Park. If you have any questions or concerns please reach out to our helpful team by WhatsApp, Phone, Email or request a call back.
